We are a computational and experimental biophysics group in the Department of Biochemistry and Biophysics at the University of North Carolina, Chapel Hill, School of Medicine. Our group is affiliated with the following programs/centers.

• Program in Cellular and Molecular Biophysics
• Carolina Center for Genome Sciences
• Bioinformatics and Computational Biology Training Program
• Neuroscience Center
• Lineberger Comprehensive Cancer Center
• Center for Computational and Systems Biology

We study the physical nature of interactions between atoms, molecules, cells, and organisms. The underlying question throughout our research is how these interactions shape the complex organization, behavior, and evolution of biomolecules and organisms. To approach this question we have been studying structure, dynamics, function, and evolution of biological molecules. Such a broad approach is necessary to tie together the diverse pieces of knowledge of molecular properties and evolution that is to us. Our present principal effort is directed towards understanding the nature of physical interactions between amino acids in proteins and the impact of these interactions on the chemical and biological properties of proteins and, at a higher level, cells and organisms.